Sabtu 3 September 2022
- Everton 0-0 Liverpool
- Brentford 5-2 Leeds United (I.Toney 30 [pen], 43', 58', B.Mbeumo 80', Y.Wissa 90'+1 - L.Sinisterra 45'+1, M.Roca 79')
- Chelsea 2-1 West Ham (B.Chilwell 76', K.Haverzt 88' - M.Antonio 63')
- Newcastle United 0-0 Crystal Palace
- Nottingham Forest 2-3 Bournemouth (C.Kouyate 33, B.Johnson 45'+2 [pen] - P.Billing 51', D.Solanke 63', J.Anthony 87')
- Tottenham Hotspur 2-1 Fulham (P.Hojbjerg 40', H.Kane 75' - A.Mitrovic 86')
- Wolves 1-0 Southampton (D.Podence 45'+1)
- Aston Villa 1-1 Manchester City (Leon Bailey 74' - Erling Haaland 50').
Minggu, 4 September 2022
- Brighton 5-2 Leicester (L.Thomas 10' [og], M.Caicedo 15', L.Trossard 64', McAllister 71' [pen], 90'+7)
- Manchester United 3-1 Arsenal (Antony Santos 35', M.Rashford 66', 75').***